Transient reactivation of Epstein-Barr virus in non chronically immunosupressed patients undergoing a short treatment with a humanized non mitogenic CD3 antibody

Bart Keymeulen; S Candon; J Seigneurin; Chantal Mathieu; A Ziegler; L. Crenier; Evy Vandemeulebroucke; M Walter; G Hale; Michel Goldman; Denis Pierard; H. Waldmann; J. F Bach; Daniel Pipeleers; Lucienne Chatenoud

Transient reactivation of Epstein-Barr virus in non chronically immunosupressed patients undergoing a short treatment with a humanized non mitogenic CD3 antibody

Bart Keymeulen, S Candon, J Seigneurin, Chantal Mathieu, A Ziegler, L. Crenier, Evy Vandemeulebroucke, M Walter, G Hale, Michel Goldman, Denis Pierard, H. Waldmann, J. F Bach, Daniel Pipeleers, Lucienne Chatenoud

Onderzoeksoutput: Editorial

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Aims/Hypothesis Insulin resistance has been proposed as a risk factor for type 1 diabetes. We investigated whether adiponectin, an insulin sensitiser, can serve as an additional predictive marker for type 1 diabetes in first-degree relatives of known patients.
Methods Adiponectin was followed in 211 persistently islet antibody-positive (Ab+) first-degree relatives of type 1 diabetic patients and in 211 age- and sex-matched persistently antibody-negative relatives, and correlated with antibody status, random proinsulin:C-peptide ratio and HLA-DQ genotype. During follow-up, 37 Ab+ relatives developed type 1 diabetes.
Results In the group of 422 relatives, baseline adiponectin correlated inversely with age and BMI and was lower in male than in female participants, especially after 15 years of age (pConclusions/Interpretation Adiponectin levels do not contribute to the prediction of type 1 diabetes in Ab+ relatives.

Originele taal-2	English
Tijdschrift	16th European Congress of Immunology, Paris France
Status	Published - 2006

Citeer dit

Keymeulen, B., Candon, S., Seigneurin, J., Mathieu, C., Ziegler, A., Crenier, L., Vandemeulebroucke, E., Walter, M., Hale, G., Goldman, M., Pierard, D., Waldmann, H., Bach, J. F., Pipeleers, D., & Chatenoud, L. (2006). Transient reactivation of Epstein-Barr virus in non chronically immunosupressed patients undergoing a short treatment with a humanized non mitogenic CD3 antibody. 16th European Congress of Immunology, Paris France.

Keymeulen, Bart ; Candon, S ; Seigneurin, J ; Mathieu, Chantal ; Ziegler, A ; Crenier, L. ; Vandemeulebroucke, Evy ; Walter, M ; Hale, G ; Goldman, Michel ; Pierard, Denis ; Waldmann, H. ; Bach, J. F ; Pipeleers, Daniel ; Chatenoud, Lucienne. / Transient reactivation of Epstein-Barr virus in non chronically immunosupressed patients undergoing a short treatment with a humanized non mitogenic CD3 antibody. In: 16th European Congress of Immunology, Paris France. 2006.

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title = "Transient reactivation of Epstein-Barr virus in non chronically immunosupressed patients undergoing a short treatment with a humanized non mitogenic CD3 antibody",

abstract = "Aims/Hypothesis Insulin resistance has been proposed as a risk factor for type 1 diabetes. We investigated whether adiponectin, an insulin sensitiser, can serve as an additional predictive marker for type 1 diabetes in first-degree relatives of known patients. Methods Adiponectin was followed in 211 persistently islet antibody-positive (Ab+) first-degree relatives of type 1 diabetic patients and in 211 age- and sex-matched persistently antibody-negative relatives, and correlated with antibody status, random proinsulin:C-peptide ratio and HLA-DQ genotype. During follow-up, 37 Ab+ relatives developed type 1 diabetes. Results In the group of 422 relatives, baseline adiponectin correlated inversely with age and BMI and was lower in male than in female participants, especially after 15 years of age (pConclusions/Interpretation Adiponectin levels do not contribute to the prediction of type 1 diabetes in Ab+ relatives.",

keywords = "CD3 ANTIBODY",

author = "Bart Keymeulen and S Candon and J Seigneurin and Chantal Mathieu and A Ziegler and L. Crenier and Evy Vandemeulebroucke and M Walter and G Hale and Michel Goldman and Denis Pierard and H. Waldmann and Bach, {J. F} and Daniel Pipeleers and Lucienne Chatenoud",

year = "2006",

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journal = "16th European Congress of Immunology, Paris France",

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Keymeulen, B, Candon, S, Seigneurin, J, Mathieu, C, Ziegler, A, Crenier, L, Vandemeulebroucke, E, Walter, M, Hale, G, Goldman, M, Pierard, D, Waldmann, H, Bach, JF, Pipeleers, D & Chatenoud, L 2006, 'Transient reactivation of Epstein-Barr virus in non chronically immunosupressed patients undergoing a short treatment with a humanized non mitogenic CD3 antibody', 16th European Congress of Immunology, Paris France.

Transient reactivation of Epstein-Barr virus in non chronically immunosupressed patients undergoing a short treatment with a humanized non mitogenic CD3 antibody. / Keymeulen, Bart; Candon, S; Seigneurin, J; Mathieu, Chantal; Ziegler, A; Crenier, L.; Vandemeulebroucke, Evy; Walter, M; Hale, G; Goldman, Michel; Pierard, Denis; Waldmann, H.; Bach, J. F; Pipeleers, Daniel; Chatenoud, Lucienne.

In: 16th European Congress of Immunology, Paris France, 2006.

Onderzoeksoutput: Editorial

TY - JOUR

T1 - Transient reactivation of Epstein-Barr virus in non chronically immunosupressed patients undergoing a short treatment with a humanized non mitogenic CD3 antibody

AU - Keymeulen, Bart

AU - Candon, S

AU - Seigneurin, J

AU - Mathieu, Chantal

AU - Ziegler, A

AU - Crenier, L.

AU - Vandemeulebroucke, Evy

AU - Walter, M

AU - Hale, G

AU - Goldman, Michel

AU - Pierard, Denis

AU - Waldmann, H.

AU - Bach, J. F

AU - Pipeleers, Daniel

AU - Chatenoud, Lucienne

PY - 2006

Y1 - 2006

N2 - Aims/Hypothesis Insulin resistance has been proposed as a risk factor for type 1 diabetes. We investigated whether adiponectin, an insulin sensitiser, can serve as an additional predictive marker for type 1 diabetes in first-degree relatives of known patients. Methods Adiponectin was followed in 211 persistently islet antibody-positive (Ab+) first-degree relatives of type 1 diabetic patients and in 211 age- and sex-matched persistently antibody-negative relatives, and correlated with antibody status, random proinsulin:C-peptide ratio and HLA-DQ genotype. During follow-up, 37 Ab+ relatives developed type 1 diabetes. Results In the group of 422 relatives, baseline adiponectin correlated inversely with age and BMI and was lower in male than in female participants, especially after 15 years of age (pConclusions/Interpretation Adiponectin levels do not contribute to the prediction of type 1 diabetes in Ab+ relatives.

AB - Aims/Hypothesis Insulin resistance has been proposed as a risk factor for type 1 diabetes. We investigated whether adiponectin, an insulin sensitiser, can serve as an additional predictive marker for type 1 diabetes in first-degree relatives of known patients. Methods Adiponectin was followed in 211 persistently islet antibody-positive (Ab+) first-degree relatives of type 1 diabetic patients and in 211 age- and sex-matched persistently antibody-negative relatives, and correlated with antibody status, random proinsulin:C-peptide ratio and HLA-DQ genotype. During follow-up, 37 Ab+ relatives developed type 1 diabetes. Results In the group of 422 relatives, baseline adiponectin correlated inversely with age and BMI and was lower in male than in female participants, especially after 15 years of age (pConclusions/Interpretation Adiponectin levels do not contribute to the prediction of type 1 diabetes in Ab+ relatives.

KW - CD3 ANTIBODY

M3 - Editorial

JO - 16th European Congress of Immunology, Paris France

JF - 16th European Congress of Immunology, Paris France

ER -

Transient reactivation of Epstein-Barr virus in non chronically immunosupressed patients undergoing a short treatment with a humanized non mitogenic CD3 antibody

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