Rationale: Liver disturbances are often observed in critically ill patients. Different etiologies are known including parenteral nutrition and drugs. The aim was to identify the 5 most used drugs with a potential hepatotoxic effect in the adult ICU.

Methods: Data on common used drugs in the period 1/1/2019 – 31/12/2019 in a 24-bed adult tertiary ICU in Brussels, Belgium were extracted from the pharmacy’s digital stock program. A list of medication with hepatotoxic profile was designed based on literature review. The use of parenteral nutrition in the same period was studied.

Results: 150.481 units of medication were listed and sorted by name and ranked by frequency of use.By comparison of both lists a top five of most frequently used hepatotoxic drugs was made: Paracetamol 1 gr intravenous (11.431 vials), amoxicillin-clavulanic acid 1gr IV (4.548 vials), flucloxacillin IV ( 1.028 vials), valproic acid IV (1.021 vials) and trimethoprim-sulfamethoxazole IV (571 vials). One thousand four hundred seventeen multi-chamber parenteral nutrition
bags were administered to the same ICU population in the same year.

Conclusion: Hepatotoxic medication and parenteral nutrition are extensively used in an adult tertiary ICU. This should be
considered in future research on Parenteral Nutrition Associated Liver Disease.
Originele taal-2English
Aantal pagina's1
StatusPublished - 4 sep 2022
EvenementESPEN Congress 2022 - Vienna, Austria
Duur: 3 sep 20226 sep 2022


ConferenceESPEN Congress 2022


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