Unveiling the intricacies of gene delivery: Caveolae-mediated endocytosis induces efficient mRNA delivery in slow-dividing cells

Sabine den Roover; Joeri L Aerts

doi:10.1016/j.omtn.2023.07.024

Unveiling the intricacies of gene delivery: Caveolae-mediated endocytosis induces efficient mRNA delivery in slow-dividing cells

Sabine den Roover, Joeri L Aerts

Onderzoeksoutput: Article › peer review

2 Citaten (Scopus)

39 Downloads (Pure)

Samenvatting

In order to unlock the full potential of gene therapy, understanding the cellular uptake mechanisms and choosing the most suitable delivery vehicle are crucially important. In the paper by Del Toro Runzer and colleagues recently published in Molecular Therapy – Nucleic Acids, the roles of the cellular uptake
mechanism, microenvironment, and cell type on the delivery of genetic materials
were extensively investigated (Figure 1).1 These insights could not only lead to
improved delivery but also to reduced cytotoxicity and beneficial therapeutic outcomes.

Originele taal-2	English
Pagina's (van-tot)	545-547
Aantal pagina's	3
Tijdschrift	Molecular Therapy Nucleic Acids
Volume	33
Vroegere onlinedatum	10 aug. 2023
DOI's	https://doi.org/10.1016/j.omtn.2023.07.024
Status	Published - 12 sep. 2023

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Publication history
Published online: August 10, 2023
Identification
DOI: https://doi.org/10.1016/j.omtn.2023.07.024

Copyright
© 2023 The Author(s).
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Creative Commons Attribution (CC BY 4.0) | How you can reuse Information Icon
ScienceDirect
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10.1016/j.omtn.2023.07.024Licentie: CC BY

1-s2.0-S216225312300197X-mainFinal published version, 1,77 MBLicentie: CC BY

Andere bestanden en links

Link naar publicatie in Scopus

FWOAL974: Ontwikkeling van een nieuwe nanopartikel formulatie voor mRNA gebaseerde therapeutische vaccinatie
Aerts, J.
1/01/20 → 31/12/22
Project: Fundamenteel

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Unveiling the intricacies of gene delivery: Caveolae-mediated endocytosis induces efficient mRNA delivery in slow-dividing cells

Samenvatting

Bibliografische nota

Toegang tot document

Andere bestanden en links

Vingerafdruk

Projecten

FWOAL974: Ontwikkeling van een nieuwe nanopartikel formulatie voor mRNA gebaseerde therapeutische vaccinatie

Citeer dit