Where Has My Efficiency Gone? Impacts of Extracolumn Peak Broadening on Performance, Part 1: Basic Concepts

Dwight Stoll, Ken Broeckhoven

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Samenvatting

Dispersion (the broadening or spreading) of analyte zones (peaks) outside of chromatography columns can seriously erode the resolution provided by good columns. Understanding the relationship between the level of dispersion associated with a given instrument relative to the intrinsic efficiency of a given column can help avoid disappointing results, especially when switching to new column technologies. In this instalment. we focus on basic concepts in extracolumn dispersion as a prelude to future instalments that will focus on dispersion in specific elements of high performance liquid chromatography (HPLC) systems.
Originele taal-2English
Pagina's (van-tot)181-188
Aantal pagina's7
TijdschriftLC-GC Europe
Volume34
Nummer van het tijdschrift5
StatusPublished - mei 2021

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