Zn-Catalyzed Nicotinate-Directed Transamidations in Peptide Synthesis

Karlijn Hollanders, Evelien Renders, Charlène Gadais, Dario Masullo, Laurent Van Raemdonck, Clarence C. D. Wybon, Charlotte Martin, Wouter A. Herrebout, Bert U. W. Maes, Steven Ballet

Onderzoeksoutput: Article

12 Citaten (Scopus)

Samenvatting

A chemoselective and catalytic transamidation for peptide synthesis is described. Transamidation under Zn catalysis is chemoselectively achieved by amino acid amide/peptidic amide derivatization with a tert-butyl nicotinate (tBu-nic) directing group. The directing group could be easily introduced on protected amino acid amides via Pd-catalyzed amidation with tert-butyl 2-chloronicotinate (tBu-nicCl). Under standard peptide coupling/deprotection conditions, the tBu-nic-equipped amino acid amides proved to be fully inert, allowing them to be easily built-in in complex molecules. The disclosed method was evaluated in the synthesis of diverse dipeptides, in dipeptide segment coupling, in side-chain modification of a solid-supported tetra-/pentapeptide, and in the macrocyclization of a heptapeptide.

Originele taal-2English
Pagina's (van-tot)4280-4289
Aantal pagina's10
TijdschriftACS Catalysis
Volume10
Nummer van het tijdschrift7
DOI's
StatusPublished - 3 apr 2020

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