Cognitive impairment in Multiple Sclerosis

: Statistical and neurophysiological aspects

Scriptie/masterproef: Doctoral Thesis


In this thesis, conducted jointly at the Vrije Universiteit Brussel (VUB)
and l’Université de Mons (UMONS) under an FWO doctoral fellowship
(aspirant mandaat), we have examined cognitive impairment and
deterioration in multiple sclerosis (MS).
MS is the most commonly encountered neurodegenerative disease in
young adults, affecting 1 out of 1000 and leading to both physical
and cognitive impairment.
In this thesis, we have analysed data collected at the
neuropsychological department at the National MS Center Melsbroek
and have answered the following neuropsychological questions:
1. Can we discern a pattern of cognitive decline in MS ?
2. How well does the Symbol Digit Modalities Test predict general
cognitive impairment?
3. What is the relative importance of cognitive and physical
impairment to a patient’s self-perceived quality of life ?
Furthermore, we have assessed the value of EEG P300 data in
detecting cognitive impairment. Being able to assess cognitive
functioning without the patient performing a complex task (like
neuropsychological tests) would eliminate practice effects and allow a
more objective assessment of cognitive impairment. For this part, we
calculated brain networks based on EEG data and calculated several
network parameters.
Datum Prijs5 mei 2015
Toekennende instantie
  • Vrije Universiteit Brussel
  • Universite de Mons
BegeleiderGuy Nagels (Promotor), Jacques De Keyser (Promotor), Marie Beatrice D'Hooghe (Promotor), Marie-Claire Haelewyck (Promotor), Johan De Mey (Jury), Bart Janssen (Jury), Dwan Langdon (Jury), Pp De Deyn (Jury) & Francis Lowenthal (Jury)

Citeer dit