SamenvattingThe thesis evaluates the value of non-invasive cardiac imaging techniques in the diagnosis of early left ventricular (LV) dysfunction in diabetes.
- In a clinical study we were able to detect from an early stage differences in diastolic function and adaptation to dobutamine stimulation with the use of transthoracic echocardiography and MIBI gated SPECT in humans with type 1 diabetes.
- During experimental studies, we evaluated a more recently developed imaging technique called myocardial velocity and deformation imaging, in the quantification of regional LV function in rats. With this technique we were able to detect, before the onset of a reduced global LV function, alterations in LV function in a rat model with streptozotocin induced diabetes. After excluding myocardial fibrosis, and by applying MIBG-SPECT imaging on this model, we also demonstrated a possible role of cardiac autonomic neuropathy in the pathogenesis of diabetic cardiomyopathy in this model. These findings should be a step forward in the non-invasive quantification of LV function in rodents. Myocardial velocity and deformation imaging should in the future be used to evaluate the effect of therapeutical interventions able to prevent or reverse myocardial disease in diabetes.
|17 dec 2009
|Guy Van Camp (Promotor), Tony Lahoutte (Co-promotor), J. D'hooge (Co-promotor), Brigitte Velkeniers-Hoebanckx (Jury), Bart Keymeulen (Jury), Danny Schoors (Jury), Christian Tielemans (Jury), H. Andersen (Jury), Johan De Sutter (Jury), Lieven Herbots (Jury) & Patrizio Lancellotti (Jury)