The main aim of the present thesis is twofold. First, to retrospectively
investigate the association between progesterone level and embryo quality,
embryo utilization rate and cumulative live birth rates, and to look into the
outcomes from oocyte donor-recipient cycles in case of progesterone
elevation. Second, to optimize freeze-all treatments, by comparing
conventional live birth rates, and reduced multiple pregnancy rates, compared
to a double embryo transfer.
The results demonstrate that elevated progesterone is associated with reduced
embryo quality and embryo utilization rate. In the first study, cumulative live
birth rate also seemed affected; however,the later study focusing on freeze-all
cycles could not confirm that finding. Oocyte donor-acceptor cycles did not
show any adverse effect of elevated progesterone levels on embryo quality nor
on any pregnancy outcome. When looking at the optimal protocol for frozen
embryo transfer, the short protocol (one week) has comparable outcomes as
the long protocol (two weeks). Also, there is no significant difference in live
birth rate comparing single embryo transfer versus double embryo transfer.
However, the rate of multiple pregnancies is significantly lower.
Datum Prijs22 sep 2020

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