Nutritional and exercise interventions to counter chronic low-grade inflammation in older adults

Scriptie/masterproef: Doctoral Thesis


Ageing is characterized by decrease in muscle strength and muscle mass (sarcopenia) and by increased levels of circulating pro-inflammatory cytokines defined as a chronic low-grade inflammatory profile (CLIP), both leading to negative health outcomes. Therefore, it is of high importance to identify how preventive and/or treatment strategies can counter CLIP in order to promote active and healthy ageing in older adults. From our systematic literature search, it seems that CLIP is not elaborately investigated, especially in frail older adults or adults with a specific condition or disease. Strength training and muscle strength appear to be the most investigated intervention and outcome, respectively. Generally, exercise interventions lead to beneficial effects on CLIP, muscle strength, body composition and physical functioning. Additionally, safety and feasibility of exercise interventions in older adults was confirmed. In our exercise intervention study, women (> 65 years) were randomized to 3months, 3x/week at either intensive strength (IST: 3x10 repetitions at 80% 1RM), strength endurance (SET: 2x30 repetitions at 40% 1RM), or flexibility (control) training. Both IST and SET, although affecting different inflammation-related pathways in peripheral blood mononuclear cells, showed beneficial effects on CLIP-related genes. Lastly, in the nutritional supplementation study, older adults were randomized into an active group (supplementation of proteins + vitamin D) or an iso-caloric control group. We found that 13 weeks of nutritional supplementation with vitamin D and leucine-enriched whey protein may attenuate the progression of CLIP in older sarcopenic persons with mobility limitations.
Datum Prijs17 sep 2019
Toekennende instantie
  • Vrije Universiteit Brussel
BegeleiderIvan Bautmans (Promotor), Ingo Beyer (Promotor), Vincent Mouly (Jury), Olivier Bruyère (Jury), Ilse Rooman (Jury), Christian Demanet (Jury) & Christel Geerts (Jury)

Citeer dit