Projects per year
Personal profile
Expertise
After completing my Master’s at the Vrije Universiteit Brussel (VUB) with great distinction, I obtained my PhD in
Medical Sciences (2025) in pancreatic cancer at the Translational Oncology Research Centre (TORC, VUB), under
mentorship of Prof. Ilse Rooman, where I currently combine research and core facility responsibilities. I work part-time
on a collaborative research project with Peking University, focused on identifying novel regulators of tumor cell
plasticity in adenosquamous carcinoma. In parallel, I serve as operational manager within the VUB
Visual and Spatial Tissue Analysis (VSTA) core facility, coordinating spatial biology projects, advising intern and extern
collaborators on experimental design and technology selection, and oversee end-to-end workflows from sample
preparation to data analysis, visualization, and interpretation.
Education/Academic qualification
Pancreatic cancer, Masters degree, Dermining the role of a potential regulator of pancreatic acinar dedifferentiation in vivo, Vrije Universiteit Brussel
Award Date: 30 Jun 2019
External positions
Employee, Innoser NV
1 Sept 2019 → …
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Collaborations and top research areas from the last five years
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Projects
- 1 Finished
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ANI356: Spatial mapping of pancreatic cancer subtypes and their microenvironmental niches
Rooman, I. (Administrative Promotor) & Michiels, E. (PI (Promotor, Principal Investigator))
1/11/23 → 31/10/24
Project: Fundamental
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AXL-Specific Single-Domain Antibodies: A Novel Diagnostic and Therapeutic Strategy in PDAC
Denis, A., Michiels, E., Baldan, J., Satilmis, H., Zhan, D., Vandewalle, N., De Bruyne, E., Menu, E., Vanderkerken, K., Breckpot, K., Devoogdt, N., Rooman, I. & De Veirman, K., 6 Feb 2026. 1 p.Research output: Unpublished contribution to conference › Poster
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Favorable histo-molecular remodeling of pancreatic ductal adenocarcinoma after neoadjuvant FOLFIRINOX followed by high-dose stereotactic body radiotherapy
Bouchart, C., Azurmendi Senar, O., Navez, J., Verset, L., Boisson, A., Hein, M., Stosic, K., Quertinmont, E., Tafciu, V., Zhao, S., Mas, L., D'Haene, N., Van Gestel, D., Moretti, L., Michiels, E., Rooman, I., Detours, V., Bachet, J.-B., Demetter, P. & Willard-Gallo, K. & 3 others, , 5 Mar 2026, In: British Journal of Cancer. 134, 5, p. 721-734 14 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Luminal–basal stratification of the native human pancreatic duct is differentially represented in pancreatic cancers
Van den Bossche, J.-L., Van der Vliet, M., Michiels, E., Azurmendi Senar, O., Van Lint, S., Madran, Z. H., Coolens, K., Brons, J., Nacher, M., Arsenijevic, T., Messaoudi, N., Lefesvre, P., Bouchart, C., Verset, L., Navez, J., Fallas, J., Dusetti, N., Montanya, E., Rovira, M. & Van Laethem, J.-L. & 3 others, , 4 Jun 2026, In: Gut. 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Spatial map of native duct cell populations in human pancreas and their representation in pancreatic cancers
Van den Bossche, J.-L., Van der Vliet, M., Michiels, E., Azurmendi Senar, O., Madran, Z., Coolens, K., Van Lint, S., Nacher, M., Arsenijevic, T., Messaoudi, N., Lefesvre, P., Montanya, E., Rovira, M., Van Laethem, J.-L., Baldan, J., Houbracken, I. & Rooman, I., 19 Jan 2025, Biorxiv, 31 p.Research output: Working paper › Preprint
Open AccessFile32 Downloads (Pure) -
Spatial Mapping of CD276 (B7-H3) in Pancreatic Ductal Adenocarcinoma indicates predominant Expression in Basal-like Tumor Ducts and αSMA⁺ Stromal Cells proximal to Tumor Epithelial Cells
De Man, V., Michiels, E., Brons, J., Espinet, E., Messaoudi, N., Olsen, C., Tuyaerts, S. & Rooman, I., 25 Sept 2025. 1 p.Research output: Unpublished contribution to conference › Poster
Datasets
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Dataset for 'High-resolution and quantitative spatial analysis reveal intra-ductal phenotypic and functional diversification in pancreatic cancer'
Michiels, E. (Creator) & Rooman, I. (Creator), VUB Institutional Data Repository, 19 Mar 2025
Dataset
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Discovery and 3D imaging of a novel ΔNp63-expressing basal cell type in human pancreatic ducts with implications in disease
Rooman, I. (Creator), Michiels, E. (Creator) & Martens, S. (Creator), VUB Institutional Data Repository, 2025
Dataset
Prizes
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Best oral presentation award: In situ detection of KRAS(G12D) mutations in the spatial context of pancreatic cancer subtypes
Michiels, E. (Recipient), 11 Oct 2022
Prize: Prize (including medals and awards)
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SPATIAL TRANSCRIPTOMICS UNCOVERS CONTEXT-DEPENDENT PHENOTYPES OF TP63/P40 EXPRESSING CELLS IN PANCREATIC CANCER
Michiels, E. (Recipient), 12 Jul 2024
Prize: Prize (including medals and awards)
Activities
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Spatial map of native duct cell populations in human pancreas and their representation in pancreatic cancers
Van den Bossche, J.-L. (Speaker), Van der Vliet, M. (Contributor), Michiels, E. (Contributor), Azurmendi Senar, O. (Contributor), Van Lint, S. (Contributor), Madran, Z. H. (Contributor), Coolens, K. (Contributor), Nacher, M. (Contributor), Arsenijevic, T. (Contributor), Lefesvre, P. (Contributor), Rovira, M. (Contributor), Montanya, E. (Contributor), Van Laethem, J.-L. (Contributor), Baldan, J. (Contributor), Houbracken, I. (Contributor) & Rooman, I. (Contributor)
4 Jul 2025Activity: Talk or presentation › Talk or presentation at a conference
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Spatial map of native duct cell populations in human pancreas and their representation in pancreatic cancers
Van den Bossche, J.-L. (Invited speaker), Van der Vliet, M. (Contributor), Michiels, E. (Contributor), Azurmendi Senar, O. (Contributor), Madran, Z. H. (Contributor), Van Lint, S. (Contributor), Coolens, K. (Contributor), Nacher, M. (Contributor), Arsenijevic, T. (Contributor), Lefesvre, P. (Contributor), Rovira, M. (Contributor), Montanya, E. (Contributor), Laethem, Van, J.-L. (Contributor), Baldan, J. (Contributor), Houbracken, I. (Contributor) & Rooman, I. (Contributor)
14 Jun 2025Activity: Talk or presentation › Talk or presentation at a conference
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SPATIAL TRANSCRIPTOMICS UNCOVERS CONTEXT-DEPENDENT PHENOTYPES OF TP63/P40 EXPRESSING CELLS IN PANCREATIC CANCER
Michiels, E. (Speaker)
11 Jul 2024 → 12 Jul 2024Activity: Talk or presentation › Talk or presentation at a conference
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A newly identified basal-luminal stratification of human pancreatic ducts is differentially recapitulated in pancreatic cancers
Van den Bossche, J.-L. (Speaker), Van der Vliet, M. (Contributor), Michiels, E. (Contributor), Azurmendi Senar, O. (Contributor), Madran, Z. H. (Contributor), Van Lint, S. (Contributor), Coolens, K. (Speaker), Nacher, M. (Contributor), Arsenijevic, T. (Contributor), Lefesvre, P. (Contributor), Rovira, M. (Contributor), Montanya, E. (Contributor), Van Laethem, J.-L. (Contributor), Baldan, J. (Contributor), Houbracken, I. (Contributor) & Rooman, I. (Contributor)
23 Oct 2024Activity: Talk or presentation › Talk or presentation at a conference
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High resolution and quantitative intra-ductal spatial analysis reveals phenotypic and functional diversification in pancreatic cancer
Michiels, E. (Speaker), Rooman, I. (Contributor), Messaoudi, N. (Contributor), Madhloum, H. (Contributor), Van Lint, S. C. (Contributor), Giron, P. (Contributor), Olsen, C. (Contributor), Dusetti, N. (Contributor) & Van Laethem, J.-L. (Contributor)
30 Apr 2023Activity: Talk or presentation › Talk or presentation at a conference
Press/Media
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Setting up a PDXO platform of pancreatic cancer with spatial-omics characterization
27/09/21
1 Media contribution
Press/Media: Public Engagement Activities
Thesis
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MECOM as a transcriptional regulator of pancreatic acinar dedifferentiation
Michiels, E. ((PhD) Student), Rooman, I. (Promotor), 30 Jun 2019Student thesis: Master's Thesis